অর্জুন ও মনসা গাছ এবং করোণা নিরাময় যোগ্যতা

359 Comments / জীববিজ্ঞান ও স্বাস্থ্য সম্বন্ধীয় / By

 

অর্জুন ও মনসা গাছ এবং করোণা নিরাময় যোগ্যতা

– ড. সুবোধ চন্দ্র গরাই

অর্জুন গাছের ছাল থেকেঃ Arjunetin - যার কোভিদ্-১৯ রোগের বিরুদ্ধে সম্ভাব্য কার্যকারিতা (Lopinavir ও Remdesivir-র তুলনায় বেশিই) রয়েছে।

      অর্জুন গাছ (বৈজ্ঞানিক নামঃ Terminalia arjuna (Roxb.) Wight & Arn এবং বিভিন্ন ভাষায় নামঃ মাঈযোকফা, अर्जुन, धनवी, इंद्रद्रुम, ककुभ, काकुभा, करवीरक, మిస్ మద్ది, மருது, குல மருது, வெல்ல மருது, வெல்ல மருது, ആറ്റുമരുത്, നീർ മറു, നിർമ്മരുത്, വെള്ളമതി, ಆತುಮರುತು, ನೀರ್ ಮರುತು, ನಿರ್ಮಟ್ಟಿ, अर्जुन, अर्जुन सदादा, सदुरा, અર્જુન, સદાદા, સેબથ, ਅਰਜੁਨ, Arjun, 阿君树, アルジュナの木, شجرة أرجون) যা Combretaceae পরিবারভূক্ত বহুবর্ষজীবি মহিরুহ জাতীয় উদ্ভিদ। এর ছালের গুঁড়া (যা অন্যান্য বহুবিধ স্বাস্থ্য উপকারিতাবহুল বিশেষতঃ হৃৎপিণ্ডের স্বাস্থ্য রক্ষায় বেশই কার্যকরী) থেকে প্রভূত পরিমাণে ফ্লেভোনয়েডের সাথে ঐ গুঁড়ার ইথানল-দ্রবনে মূলতঃ পাইসিন (5 6-Membered Fused Hydrocarbon ring structure) কাঠামোয় গঠিত ওলিয়ানেন নামক জৈব-যৌগের পরিবর্তিত রূপে Oleanolic Acid, Arjunic Acid, Arjunolic Acid, Arjunolitin, Arjunetin প্রভৃতি ফাইটোকেমিক্যাল পাওয়া যায়। In silico, Molecular Docking পদ্ধতি [তথ্যসূত্রঃ (১) “Structural insights on the interaction potential of natural leads against major protein targets of SARS-CoV-2: Molecular modelling, docking and dynamic simulation studies ও (২) “Structural Basis of Potential Inhibitors Targeting SARS-CoV-2 Main Protease”] প্রয়োগ করে এদের মধ্যে অর্জুনেটিন যৌগটি নিয়ে পরীক্ষায় অধুনা দেখা গেছে যে, এটি কোভিদ্-১৯ রোগ সৃষ্টিকারী সার্স-কোভ-২ নামক ভাইরাসের ৩টি প্রোটীজ্ (3CL, PL ও RdRP) উৎসেচকের কর্মক্ষমতা-নিবারক (ফলে, ভাইরাস সংখ্যা-বৃদ্ধিতে অপারগ, তথ্যসূত্রঃ “Potential of Terminalia arjuna as a Promising Phytoremedy Against COVID-19: DPPH Scavenging, Catalase Inhibition and Molecular Docking Studies”)। ঐ রোগ-নিরাময় উদ্দেশ্যে বহুল ব্যবহৃত ২টি ওষুধ, যথা Lopinavir ও Remdesivir-এর তুলনায় অর্জুনেটিন যৌগটি বেশি উপযোগী তথা কার্যকরী। এই অনুচ্ছেদের মোট ৩টি ওয়েব-লিঙ্কেরই প্রথম ২টি একই ধরণের গবেষণাপত্রে আরও কয়েকটি অনুরূপভাবে ঐ রোগের জন্য উপযোগী ফাইটোকেমিক্যালের সম্ভাব্য ক্ষমতা সম্পর্কেও জানানো হয়েছে – অন্যতম হল Hyoscyamine যা Solanaceae পরিবারের ধুতুরা তথা Datura metel Linn.

ফল ও ফুল সহ ধুতুরা গাছ (Datura metel Linn.)

এবং ডঙ্কা ফুল গাছ তথা Brugmansia suaveolens (Humb. & Bonpl. ex Willd.)

ফুল সহ ডঙ্কা ফুল গাছ (Brugmansia suaveolens (Humb. & Bonpl. ex Willd.)

প্রভৃতি উদ্ভিদ থেকেও লভ্য।

      অধিকন্তু, মনসা গাছ (বৈজ্ঞানিক নামঃ Euphorbia nerifolia Linnaeus এবং বিভিন্ন ভাষায় নামঃ দুধসর, সেন্দ, সেন্দ মনসা, সেহুন্দ মনসা, মনসাসিজ, সিজু, সৰু সিজু, তেঙনৌ, डंडा ठौर, डंडा थौर, सेहड़, सेहुंड, सेहड़, सेहुंड, गुढ़ा, नागरिका, नंदा, निस्त्रिनसापत्र, पत्रस्नुही, स्नूही, वज्र, विजरी, पत्रसनुक, स्वरसना, उपविशा, ﭨﮭﹹﮩﺮ, ଗୁଡ଼ା, ଥୋର, କାଣ୍ଡାଲୋଥୋର, అకు-జెముడు, అకుజముడు, இலைக்கள்ளி, பெரும்பு கள்ளி, ഇലകൾ, ഇലകൾ, ഇലകൾ, ಎಲೆಗಳ್ಳಿ, ಎಲೆಕಳ್ಳಿ, ಇಳೈಕಲ್ಲಿ, मिंगुट, नेवागुंडा, नेवरंग, થૂવર, ભુંગરા ચોર, ਥੋਰ, Indian spurge tree, Oleander spurge, Oleander leafed euphorbia, Hedge euphorbia, Common milk hedge, Holy milk hedge, Milkbush, Молочай олеандролистный, Dog’s tongue, 对冲大戟, 對沖大戟, 金刚纂, ヘッジユーフォルビア, ديهو مينجوتا, جاكوم, කොළ පතොක්, පතක්, သဆောင်၊, သဇုံမန, ส้มเช้า) যার কাণ্ড-কণ্টকিত, Euphorbiaceae পরিবারভূক্ত মাঝারী উচ্চতার বহুবর্ষজীবি মহিরুহ জাতীয় উদ্ভিদ।

মনসা গাছ (Euphorbia nerifolia Linnaeus)

      এই গাছটির পাতার নির্যাসও অল্প ও মাঝারী মাত্রায় করোণা সংক্রমণে নিরাময় উদ্দেশ্যে ব্যাপকভাবে বাংলাদেশে ব্যবহৃত হয়েছে (তথ্যসূত্রঃ “Euphorbia neriifolia Leaf Juice on Mild and Moderate COVID-19 Patients: Implications in OMICRON Era”) এবং একই উদ্দেশ্যে ফিলিপাইন্স দ্বীপপূঞ্জেও এর ব্যবহারের সম্ভাবনার কথা জানা গেছে (তথ্যসূত্রঃ “Philippine Medicinal Plants with Potential Immunomodulatory and Anti-SARS-CoV-2 Activities”) – প্রাসঙ্গিক আরও ২টি তথ্যসূত্র হলঃ (১) “Natural products’ role against COVID-19“ এবং (২) “Anti-Human Coronavirus (anti-HCoV) Triterpenoids from the Leaves of Euphorbia neriifolia“ ।

অনুসন্ধানের উদ্দেশ্যে, এখানে উল্লিখিত ঐ ৪টি গাছ সহ এপর্যন্ত ৪২১টি গাছ-গাছড়া ও লতা-গুল্ম (সংস্লিষ্ট সারণীটি সংযোজন, সম্প্রসারণ, সংশোধন ও সাম্প্রতিকিকরণ চলছে) সম্পর্কে ছবি, ভিডিও, বিবরণ-গুণাগুণ, গবেষণা প্রভৃতির লিঙ্ক সহ অতি বিস্তারিত তথ্যাবলী যেখানে লভ্য সেই লিঙ্কটি হলঃ

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